Posttranscriptional Crossregulation between Drosha and DGCR8
نویسندگان
چکیده
منابع مشابه
Posttranscriptional Crossregulation between Drosha and DGCR8
The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and DGCR8 are regulated and if these proteins have any additional role(s) apart fr...
متن کاملThe Drosha-DGCR8 complex in primary microRNA processing.
RNase III proteins play key roles in microRNA (miRNA) biogenesis. The nuclear RNase III Drosha cleaves primary miRNAs (pri-miRNAs) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic RNase III Dicer to generate mature miRNAs. While Dicer (class III) and other simple RNase III proteins (class I) have been studied intensively, the class II enzyme Drosha remains to be...
متن کاملMeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex.
Loss- and gain-of-function mutations of the X-linked gene MECP2 (methyl-CpG binding protein 2) lead to severe neurodevelopmental disorders in humans, such as Rett syndrome (RTT) and autism. MeCP2 is previously known as a transcriptional repressor by binding to methylated DNA and recruiting histone deacetylase complex (HDAC). Here, we report that MeCP2 regulates gene expression posttranscription...
متن کاملارزیابی میزان آنزیمهای Drosha، Dicer و پروتئین DGCR8 در بیماران مبتلا به پرهاکلامپسی
مقدمه: پرهاکلامپسی به عنوان یک اختلال مهم دوران بارداری شناخته شده است که با افزایش فشارخون در نیمه دوم بارداری و پروتئینوری همراه میباشد و یکی از سه عامل اصلی مرگ‌و‌میر مادر و جنین به شمار میآید. بی‌نظمی در میکروRANها با مکانسیم تأثیر بر عوامل رگزایی، در پرهاکلامپسی نقش دارند و میتوانند برای تشخیص این بیماری به‌کار روند.مطالعه حاضر با هدف بررسی میزان بیان ژن‌هایDGCR8 ،Dicer و Drosha در ب...
متن کاملMolecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex
The Drosha-DGCR8 complex initiates microRNA maturation by precise cleavage of the stem loops that are embedded in primary transcripts (pri-miRNAs). Here we propose a model for this process that is based upon evidence from both computational and biochemical analyses. A typical metazoan pri-miRNA consists of a stem of approximately 33 bp, with a terminal loop and flanking segments. The terminal l...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2008.10.053